diff --git a/dev-requirements.txt b/dev-requirements.txt
index 7b0e96c8..eba66348 100644
--- a/dev-requirements.txt
+++ b/dev-requirements.txt
@@ -12,12 +12,11 @@ flake8-import-order
 mock
 
 # Test runners
-nose
+pytest
+pytest-cov
+pytest-xdist
 tox
 
-# Measure test's code coverage
-coverage
-
 # Check that MANIFEST.in matches Git repo contents before making a release
 check-manifest
 
diff --git a/docs/contributing.rst b/docs/contributing.rst
index 165fee49..f30e16bd 100644
--- a/docs/contributing.rst
+++ b/docs/contributing.rst
@@ -89,11 +89,11 @@ Mopidy to come with tests.
 
 #. To run all tests, go to the project directory and run::
 
-       nosetests
+       py.test
 
    To run tests with test coverage statistics::
 
-       nosetests --with-coverage
+       py.test --cov=mopidy --cov-report=term-missing
 
    Test coverage statistics can also be viewed online at
    `coveralls.io <https://coveralls.io/r/mopidy/mopidy>`_.
diff --git a/docs/extensiondev.rst b/docs/extensiondev.rst
index c6a88619..93f627dc 100644
--- a/docs/extensiondev.rst
+++ b/docs/extensiondev.rst
@@ -189,11 +189,6 @@ class that will connect the rest of the dots.
             'Pykka >= 1.1',
             'pysoundspot',
         ],
-        test_suite='nose.collector',
-        tests_require=[
-            'nose',
-            'mock >= 1.0',
-        ],
         entry_points={
             'mopidy.ext': [
                 'soundspot = mopidy_soundspot:Extension',
diff --git a/setup.py b/setup.py
index 384aaec5..0d29c041 100644
--- a/setup.py
+++ b/setup.py
@@ -29,11 +29,6 @@ setup(
         'tornado >= 2.3',
     ],
     extras_require={'http': []},
-    test_suite='nose.collector',
-    tests_require=[
-        'nose',
-        'mock >= 1.0',
-    ],
     entry_points={
         'console_scripts': [
             'mopidy = mopidy.__main__:main',
diff --git a/tasks.py b/tasks.py
index 7b5692e3..9353eb8a 100644
--- a/tasks.py
+++ b/tasks.py
@@ -15,11 +15,9 @@ def test(path=None, coverage=False, watch=False, warn=False):
     if watch:
         return watcher(test, path=path, coverage=coverage)
     path = path or 'tests/'
-    cmd = 'nosetests'
+    cmd = 'py.test'
     if coverage:
-        cmd += (
-            ' --with-coverage --cover-package=mopidy'
-            ' --cover-branches --cover-html')
+        cmd += ' --cov=mopidy --cov-report=term-missing'
     cmd += ' %s' % path
     run(cmd, pty=True, warn=warn)
 
diff --git a/tests/__main__.py b/tests/__main__.py
deleted file mode 100644
index ae7a18e6..00000000
--- a/tests/__main__.py
+++ /dev/null
@@ -1,5 +0,0 @@
-from __future__ import absolute_import, unicode_literals
-
-import nose
-
-nose.main()
diff --git a/tox.ini b/tox.ini
index 277ae9d3..3d48e311 100644
--- a/tox.ini
+++ b/tox.ini
@@ -3,20 +3,20 @@ envlist = py27, py27-tornado23, py27-tornado31, docs, flake8
 
 [testenv]
 sitepackages = true
-commands = nosetests -v --with-xunit --xunit-file=xunit-{envname}.xml --with-coverage --cover-package=mopidy
+commands = py.test --junit-xml=xunit-{envname}.xml --cov=mopidy
 deps =
-    coverage
     mock
-    nose
+    pytest
+    pytest-cov
 
 [testenv:py27-tornado23]
-commands = nosetests -v tests/http
+commands = py.test tests/http
 deps =
     {[testenv]deps}
     tornado==2.3
 
 [testenv:py27-tornado31]
-commands = nosetests -v tests/http
+commands = py.test tests/http
 deps =
     {[testenv]deps}
     tornado==3.1.1